Polycystic kidney disease in the C57BL/6J (cpk) mouse is an autosomal recessive disorder
which leads to the rapid development of renal cysts and kidney failure during the first 3 to 4
postnatal weeks. Previously, we showed that the cystic kidneys of affected mice have
abnormally elevated levels of c-myc mRNA. In the study presented here, it is shown that
mRNAs for the proto-oncogenes c-fos and c-Kiras, as well as c-myc, are markedly elevated
in cystic kidneys, suggesting that there is a more general abnormality in gene expression …