Phylogenetic Analysis of the Apolipoprotein B mRNA-editing Region: EVIDENCE FOR A SECONDARY STRUCTURE BETWEEN THE MOORING SEQUENCE AND …
M Hersberger, S Patarroyo-White, KS Arnold… - Journal of Biological …, 1999 - jbc.org
Apolipoprotein (apo) B mRNA editing is the deamination of C 6666 to uridine, which
changes the codon at position 2153 from a genomically encoded glutamine (CAA) to an in-
frame stop codon (UAA). The apoB mRNA-editing enzyme complex recognizes the editing
region of the apoB pre-mRNA with exquisite precision. Four sequence elements spanning
139 nucleotides (nt) on the apoB mRNA have been identified that specify this precision. In
cooperation with the indispensable mooring sequence and spacer element, a 5′ efficiency …
changes the codon at position 2153 from a genomically encoded glutamine (CAA) to an in-
frame stop codon (UAA). The apoB mRNA-editing enzyme complex recognizes the editing
region of the apoB pre-mRNA with exquisite precision. Four sequence elements spanning
139 nucleotides (nt) on the apoB mRNA have been identified that specify this precision. In
cooperation with the indispensable mooring sequence and spacer element, a 5′ efficiency …
