[HTML][HTML] The role of phosphoinositide 3-kinase lipid products in cell function
LE Rameh, LC Cantley - Journal of Biological Chemistry, 1999 - ASBMB
Phosphoinositide 3-kinases (PI 3-Ks) 1 are a subfamily of lipid kinases that catalyze the
addition of a phosphate molecule specifically to the 3-position of the inositol ring of
phosphoinositides. Phosphatidylinositol (PtdIns), the precursor of all phosphoinositides (PI),
constitutes less than 10% of the total lipid in eukaryotic cell membranes (Fig. 1).
Approximately 5% of cellular PI is phosphorylated at the 4-position (PtdIns-4-P), and another
5% is phosphorylated at both the 4-and 5-positions (PtdIns-4, 5-P2). However, less than …
addition of a phosphate molecule specifically to the 3-position of the inositol ring of
phosphoinositides. Phosphatidylinositol (PtdIns), the precursor of all phosphoinositides (PI),
constitutes less than 10% of the total lipid in eukaryotic cell membranes (Fig. 1).
Approximately 5% of cellular PI is phosphorylated at the 4-position (PtdIns-4-P), and another
5% is phosphorylated at both the 4-and 5-positions (PtdIns-4, 5-P2). However, less than …