[HTML][HTML] A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3-Kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85α Gene (∗)
K Inukai, M Anai, E Van Breda, T Hosaka… - Journal of Biological …, 1996 - ASBMB
Phosphatidylinositol 3-kinase, which is composed of a 110-kDa catalytic subunit and a
regulatory subunit, plays important roles in various cellular signaling mechanisms. We
screened a rat brain cDNA expression library with 32 P-labeled human IRS-1 protein and
cloned cDNAs that were very likely to be generated by alternative splicing of p85α gene
products. These cDNAs were demonstrated to encode a 55-kDa protein (p55α) containing
two SH2 domains and an inter-SH2 domain of p85α but neither a bcr domain nor a SH3 …
regulatory subunit, plays important roles in various cellular signaling mechanisms. We
screened a rat brain cDNA expression library with 32 P-labeled human IRS-1 protein and
cloned cDNAs that were very likely to be generated by alternative splicing of p85α gene
products. These cDNAs were demonstrated to encode a 55-kDa protein (p55α) containing
two SH2 domains and an inter-SH2 domain of p85α but neither a bcr domain nor a SH3 …