[HTML][HTML] Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110α subunit of phosphoinositide 3-kinase
L Bi, I Okabe, DJ Bernard, A Wynshaw-Boris… - Journal of Biological …, 1999 - ASBMB
Phosphatidylinositol 3, 4, 5-trisphosphate is a phospholipid signaling molecule involved in
many cellular functions including growth factor receptor signaling, cytoskeletal organization,
chemotaxis, apoptosis, and protein trafficking. Phosphorylation at the 3 position of the
inositol ring is catalyzed by many different 3-kinases (classified as types IA, IB, II, and III), but
the physiological roles played by each of the different 3-kinase isozymes during embryonic
development and in homeostasis in animals is incompletely understood. Mammalian type IA …
many cellular functions including growth factor receptor signaling, cytoskeletal organization,
chemotaxis, apoptosis, and protein trafficking. Phosphorylation at the 3 position of the
inositol ring is catalyzed by many different 3-kinases (classified as types IA, IB, II, and III), but
the physiological roles played by each of the different 3-kinase isozymes during embryonic
development and in homeostasis in animals is incompletely understood. Mammalian type IA …