[HTML][HTML] Insulin Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression Does Not Require Activation of the Ras/Mitogen-activated Protein Kinase …
RA Gabbay, C Sutherland, L Gnudi, BB Kahn… - Journal of Biological …, 1996 - ASBMB
Expression of phosphoenolpyruvate carboxykinase (PEPCK), the rate-limiting step in
hepatic gluconeogenesis, is primarily regulated at the level of gene transcription. Insulin and
phorbol esters inhibit basal PEPCK transcription and antagonize the induction of PEPCK
gene expression by glucocorticoids and glucagon (or its second messenger cAMP). Insulin
activates a signaling cascade involving Ras→ Raf→ p42/p44 mitogen-activated protein
(MAP) kinase kinase (MEK)→ p42/p44 MAP kinase (ERK 1 and 2). Recent reports suggest …
hepatic gluconeogenesis, is primarily regulated at the level of gene transcription. Insulin and
phorbol esters inhibit basal PEPCK transcription and antagonize the induction of PEPCK
gene expression by glucocorticoids and glucagon (or its second messenger cAMP). Insulin
activates a signaling cascade involving Ras→ Raf→ p42/p44 mitogen-activated protein
(MAP) kinase kinase (MEK)→ p42/p44 MAP kinase (ERK 1 and 2). Recent reports suggest …