The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

AH Berg, TP Combs, X Du, M Brownlee, PE Scherer - Nature medicine, 2001 - nature.com
AH Berg, TP Combs, X Du, M Brownlee, PE Scherer
Nature medicine, 2001nature.com
Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of
purified recombinant Acrp30 leads to a 2–3-fold elevation in circulating Acrp30 levels, which
triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-
obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This
effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated
hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress …
Abstract
Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2–3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.
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