[CITATION][C] Cytokines: coordinators of immune and inflammatory responses
K Arai, F Lee, A Miyajima, S Miyatake… - Annual review of …, 1990 - annualreviews.org
Proliferation and differentiation of mammalian cells are generally controlled by extracellular
signals. Among these signals are a group of polypeptide growth factors and differentiation
factors such as EGF, NGF, PDGF, and FGF. More recently, a battery of lymphokines and
monokines produced by activated T cells or macrophages have been added to this
catalogue. Gly coproteins such as IL-I, IL-2, IL-3, IL-4, IL-5, IL-6, GM-CSF, G-CSF, IFN-,}" TNF-
a, and lymphotoxin mediate immune and inflammatory re sponses. Likewise, factors …
signals. Among these signals are a group of polypeptide growth factors and differentiation
factors such as EGF, NGF, PDGF, and FGF. More recently, a battery of lymphokines and
monokines produced by activated T cells or macrophages have been added to this
catalogue. Gly coproteins such as IL-I, IL-2, IL-3, IL-4, IL-5, IL-6, GM-CSF, G-CSF, IFN-,}" TNF-
a, and lymphotoxin mediate immune and inflammatory re sponses. Likewise, factors …
