[HTML][HTML] Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4
SH Kim, CH Evans, S Kim, T Oligino… - Arthritis Research & …, 2000 - Springer
SH Kim, CH Evans, S Kim, T Oligino, SC Ghivizzani, PD Robbins
Arthritis Research & Therapy, 2000•SpringerStatement of findings To determine whether IL-4 is therapeutic in treating established
experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4
(Ad-mIL-4) was used for periarticular injection into the ankle joints into mice with established
collagen-induced arthritis (CIA). Periarticular injection of Ad-mIL-4 resulted in a reduction in
the severity of arthritis and joint swelling compared with saline-and adenoviral control
groups. Local expression of IL-4 also reduced macroscopic signs of joint inflammation and …
experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4
(Ad-mIL-4) was used for periarticular injection into the ankle joints into mice with established
collagen-induced arthritis (CIA). Periarticular injection of Ad-mIL-4 resulted in a reduction in
the severity of arthritis and joint swelling compared with saline-and adenoviral control
groups. Local expression of IL-4 also reduced macroscopic signs of joint inflammation and …
Statement of findings
To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4 (Ad-mIL-4) was used for periarticular injection into the ankle joints into mice with established collagen-induced arthritis (CIA). Periarticular injection of Ad-mIL-4 resulted in a reduction in the severity of arthritis and joint swelling compared with saline- and adenoviral control groups. Local expression of IL-4 also reduced macroscopic signs of joint inflammation and bone erosion. Moreover, injection of Ad-mIL-4 into the hind ankle joints resulted in a decrease in disease severity in the untreated front paws. Systemic delivery of murine IL-4 by intravenous injection of Ad-mIL-4 resulted in a significant reduction in the severity of early-stage arthritis.
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