G protein-coupled receptor agonists initiate a cascade of signaling events in neonatal rat
ventricular myocytes that culminates in changes in gene expression and cell growth
characteristic of hypertrophy. These responses have been previously shown to be
dependent on G q and Ras. Rho, a member of the Ras superfamily of GTPases, regulates
cytoskeletal rearrangement and transcriptional activation of the c-fos serum response
element. Immunofluorescence staining of cardiomyocytes shows that Rho is present and …