Thyroid failure in the elderly: microsomal antibodies as discriminant for therapy
MJ Rosenthal, WC Hunt, PJ Garry, JS Goodwin - Jama, 1987 - jamanetwork.com
Thyrotropin (thyroid-stimulating hormone [TSH]) levels were elevated above 4.0 mU/L
(μU/mL) in serum samples from 13.2% of 258 healthy elderly subjects. To investigate the
natural history of progressive thyroid failure, serial thyroid functions were measured for four
years in 26 of these subjects with elevated TSH levels. In one third of these subjects,
biochemical thyroid failure developed (thyroxine level< 58 nmol/L [4.5 μg/dL]) within the
course of the study. All subjects with initial TSH levels above 20 mU/L (μU/mL), and 80% of …
(μU/mL) in serum samples from 13.2% of 258 healthy elderly subjects. To investigate the
natural history of progressive thyroid failure, serial thyroid functions were measured for four
years in 26 of these subjects with elevated TSH levels. In one third of these subjects,
biochemical thyroid failure developed (thyroxine level< 58 nmol/L [4.5 μg/dL]) within the
course of the study. All subjects with initial TSH levels above 20 mU/L (μU/mL), and 80% of …
