WD40 repeat proteins striatin and S/G2 nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A
CS Moreno, S Park, K Nelson, D Ashby… - Journal of Biological …, 2000 - jbc.org
Protein phosphatase 2A (PP2A) is a multifunctional serine/threonine phosphatase that is
critical to many cellular processes including development, neuronal signaling, cell cycle
regulation, and viral transformation. PP2A has been implicated in Ca 2+-dependent
signaling pathways, but how PP2A is targeted to these pathways is not understood. We have
identified two calmodulin (CaM)-binding proteins that form stable complexes with the PP2A
A/C heterodimer and may represent a novel family of PP2A B-type subunits. These two …
critical to many cellular processes including development, neuronal signaling, cell cycle
regulation, and viral transformation. PP2A has been implicated in Ca 2+-dependent
signaling pathways, but how PP2A is targeted to these pathways is not understood. We have
identified two calmodulin (CaM)-binding proteins that form stable complexes with the PP2A
A/C heterodimer and may represent a novel family of PP2A B-type subunits. These two …
