An analysis of regulatory elements in the phosphoenolpyruvate carboxykinase (GTP) gene which are responsible for its tissue-specific expression and metabolic …

YM Patel, JS Yun, J Liu, MM McGrane… - Journal of Biological …, 1994 - ASBMB
Sequences in the gene for P-enolpyruvate carboxykinase (PEPCK) which are responsible
for its complex pattern of transcriptional control were determined using transgenic mice
containing a chimeric PEPCK-bovine growth hormone (bGH) gene consisting of a segment
of the PEPCK promoter from-460 to+ 73, with mutations in specific regulatory domains. A
mutation in the cAMP response element (CRE)(-87 to-74), which binds CCATT/enhancer-
binding protein beta (C/EBP beta) and/or cAMP response element-binding protein (CREB) …