[HTML][HTML] The molecular physiology of hepatic nuclear factor 3 in the regulation of gluconeogenesis
Glucocorticoids stimulate gluconeogenesis by increasing the rate of transcription of genes
that encode gluconeogenic enzymes such as phosphoenolpyruvate carboxykinase
(PEPCK) and glucose-6-phosphatase. Previous studies have shown that hepatic nuclear
factor 3 (HNF3) is required as an accessory factor for several glucocorticoid-stimulated
genes, including PEPCK. Here, we show that adenovirus-mediated expression of an HNF3β
protein with a deleted C-terminal transactivation domain (HNF3βΔC) reduces the …
that encode gluconeogenic enzymes such as phosphoenolpyruvate carboxykinase
(PEPCK) and glucose-6-phosphatase. Previous studies have shown that hepatic nuclear
factor 3 (HNF3) is required as an accessory factor for several glucocorticoid-stimulated
genes, including PEPCK. Here, we show that adenovirus-mediated expression of an HNF3β
protein with a deleted C-terminal transactivation domain (HNF3βΔC) reduces the …