[HTML][HTML] Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein …
Insulin inhibits the expression of multiple genes in the liver containing an insulin response
sequence (IRS)(CAAAA (C/T) AA), and we have reported that protein kinase B (PKB)
mediates this effect of insulin. Genetic studies inCaenorhabditis elegans indicate that daf-16,
aforkhead/winged-helix transcription factor, is a major target of the insulin receptor-PKB
signaling pathway. FKHR, a human homologue of daf-16, contains three PKB sites and is
expressed in the liver. Reporter gene studies in HepG2 hepatoma cells show that FKHR …
sequence (IRS)(CAAAA (C/T) AA), and we have reported that protein kinase B (PKB)
mediates this effect of insulin. Genetic studies inCaenorhabditis elegans indicate that daf-16,
aforkhead/winged-helix transcription factor, is a major target of the insulin receptor-PKB
signaling pathway. FKHR, a human homologue of daf-16, contains three PKB sites and is
expressed in the liver. Reporter gene studies in HepG2 hepatoma cells show that FKHR …