Effect of acute alterations in acid-base balance on rat renal glutaminase and phosphoenolpyruvate carboxykinase gene expression
JJ Hwang, NP Curthoys - Journal of Biological Chemistry, 1991 - ASBMB
During chronic acidosis, the levels of the rat renal mRNAs that encode the mitochondrial
glutaminase (GA) and cytosolic phosphoenolpyruvate carboxykinase (PCK) are increased 6-
fold. Following acute recovery of chronic acidosis, the levels of the two mRNAs are rapidly
and coordinately decreased, returning to normal within 13-17 h. In contrast, the increases in
GA and PCK mRNAs during acute onset of acidosis occur with very different kinetics. The
increase in PCK mRNA occurs rapidly and reaches a maximum within 7 h, whereas the GA …
glutaminase (GA) and cytosolic phosphoenolpyruvate carboxykinase (PCK) are increased 6-
fold. Following acute recovery of chronic acidosis, the levels of the two mRNAs are rapidly
and coordinately decreased, returning to normal within 13-17 h. In contrast, the increases in
GA and PCK mRNAs during acute onset of acidosis occur with very different kinetics. The
increase in PCK mRNA occurs rapidly and reaches a maximum within 7 h, whereas the GA …