Characterization of a zinc finger gene disrupted by the t (15; 17) in acute promyelocytic leukemia
AD Goddard, J Borrow, PS Freemont, E Solomon - Science, 1991 - science.org
AD Goddard, J Borrow, PS Freemont, E Solomon
Science, 1991•science.orgThe translocation t (15; 17) associated with acute promyelocytic leukemia results in the
fusion of the retinoic acid receptor alpha (RARA) gene to the PML gene. Characterization of
PML revealed that it is a putative zinc finger protein and potential transcription factor that is
commonly expressed, with at least three major transcription products. PML breakpoints
cluster in two regions on either side of an alternatively spliced exon. Although leukemic cells
with translocations characteristically express only one fusion product, both PML/RARA (on …
fusion of the retinoic acid receptor alpha (RARA) gene to the PML gene. Characterization of
PML revealed that it is a putative zinc finger protein and potential transcription factor that is
commonly expressed, with at least three major transcription products. PML breakpoints
cluster in two regions on either side of an alternatively spliced exon. Although leukemic cells
with translocations characteristically express only one fusion product, both PML/RARA (on …
The translocation t(15;17) associated with acute promyelocytic leukemia results in the fusion of the retinoic acid receptor alpha (RARA) gene to the PML gene. Characterization of PML revealed that it is a putative zinc finger protein and potential transcription factor that is commonly expressed, with at least three major transcription products. PML breakpoints cluster in two regions on either side of an alternatively spliced exon. Although leukemic cells with translocations characteristically express only one fusion product, both PML/RARA (on the 15q+ derivative chromosome) and RARA/PML (on the 17q- derivative) are transcribed.
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