Adipocyte differentiation: a transcriptional regulatory cascade

RP Brun, JB Kim, E Hu, S Altiok… - Current opinion in cell …, 1996 - Elsevier
RP Brun, JB Kim, E Hu, S Altiok, BM Spiegelman
Current opinion in cell biology, 1996Elsevier
The adipose cell is now known to play a complex role in energy homeostasis, energy
storage and signaling to other tissues concerning the state of energy balance. The past few
years have seen an explosive increase in our knowledge of the transcriptional basis of
adipocyte differentiation. Factors such as peroxisome proliferator-activated receptor γ, the
CCAAT/enhancer binding protein family members, and adipocyte determination-and
differentiation-dependent factor 1 play important regulatory roles in this process …
The adipose cell is now known to play a complex role in energy homeostasis, energy storage and signaling to other tissues concerning the state of energy balance. The past few years have seen an explosive increase in our knowledge of the transcriptional basis of adipocyte differentiation. Factors such as peroxisome proliferator-activated receptor γ, the CCAAT/enhancer binding protein family members, and adipocyte determination- and differentiation-dependent factor 1 play important regulatory roles in this process. Furthermore, these factors provide a focus for beginning to understand how various hormones and metabolites influence the development of adipose tissue in vivo.
Elsevier