The CD1 family of lipid antigen-presenting molecules
SA Porcelli, BW Segelke, M Sugita, IA Wilson… - Immunology today, 1998 - cell.com
SA Porcelli, BW Segelke, M Sugita, IA Wilson, MB Brenner
Immunology today, 1998•cell.comThe paradigm that T cells recognize peptide antigens presented by major histocompatibility
complex class I and class II molecules has been a guiding principle in the development of
immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm
by showing that CD1 proteins are a separate lineage of antigen-presenting molecules with
unusually hydrophobic ligand-binding grooves that present nonpeptide lipid and glycolipid
antigens to T cells.
complex class I and class II molecules has been a guiding principle in the development of
immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm
by showing that CD1 proteins are a separate lineage of antigen-presenting molecules with
unusually hydrophobic ligand-binding grooves that present nonpeptide lipid and glycolipid
antigens to T cells.
Abstract
The paradigm that T cells recognize peptide antigens presented by major histocompatibility complex class I and class II molecules has been a guiding principle in the development of immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm by showing that CD1 proteins are a separate lineage of antigen-presenting molecules with unusually hydrophobic ligand-binding grooves that present nonpeptide lipid and glycolipid antigens to T cells.
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