Teratogenic effect of an inhibitor of cholesterol synthesis (AY 9944) in rats: correlation with maternal cholesterolemia
CH Roux, R Dupuis, C Horvath, JN Talbot - The Journal of nutrition, 1980 - jn.nutrition.org
The teratogenic action of AY 9944, an inhibitor of cholesterol synthesis, was previously
shown. Its prevention by simultaneous administration of cholesterol led to the hypothesis
that this action is correlated with the decrease in cholesterol. The present investigation
demonstrates that there is an inverse correlation between holoprosencephalic type of
malformations and maternal cholesterolemia and that, in Wistar rats, 0.30 g/liter of
cholesterolemia is a threshold under which these malformations can be observed.
shown. Its prevention by simultaneous administration of cholesterol led to the hypothesis
that this action is correlated with the decrease in cholesterol. The present investigation
demonstrates that there is an inverse correlation between holoprosencephalic type of
malformations and maternal cholesterolemia and that, in Wistar rats, 0.30 g/liter of
cholesterolemia is a threshold under which these malformations can be observed.