Discordant effects on eicosanoids and fibrin degradation products in two murine models of antiphospholipid antibody
AE Schorer - Thrombosis research, 1997 - Elsevier
Two murine models of lupus were employed to challenge an hypothesized mechanism by
which antiphospholipid antibodies (APLA) might promote thrombosis: altering prostacyclin
(PGI2) and thromboxane (TX) production. PGI2 levels in mouse blood and the ex vivo
release of PGI2 and TX from mouse kidney were measured. Since APLA have been
reported to alter synthesis or activation of several molecules mediating fibrinolysis, murine
plasma levels of the fibrin degradation product, D-dimer were also determined. Two murine …
which antiphospholipid antibodies (APLA) might promote thrombosis: altering prostacyclin
(PGI2) and thromboxane (TX) production. PGI2 levels in mouse blood and the ex vivo
release of PGI2 and TX from mouse kidney were measured. Since APLA have been
reported to alter synthesis or activation of several molecules mediating fibrinolysis, murine
plasma levels of the fibrin degradation product, D-dimer were also determined. Two murine …