Constitutively active mutant of the mitogen-activated protein kinase kinase MEK1 induces epithelial dedifferentiation and growth inhibition in madin-darby canine …
H Schramek, E Feifel, E Healy, V Pollack - Journal of Biological Chemistry, 1997 - jbc.org
Overexpression of a constitutively active mitogen-activated protein kinase kinase (MAPKK or
MEK) induces neuronal differentiation in adrenal pheochromocytoma 12 cells but
transformation in fibroblasts. In the present study, we used a constitutively active
MAPK/extracellular signal-regulated kinase (ERK) kinase 1 (MEK1) mutant to investigate the
function of the highly conserved MEK1-ERK2 signaling module in renal epithelial cell
differentiation and proliferation. Stable expression of constitutively active MEK1 (CA-MEK1) …
MEK) induces neuronal differentiation in adrenal pheochromocytoma 12 cells but
transformation in fibroblasts. In the present study, we used a constitutively active
MAPK/extracellular signal-regulated kinase (ERK) kinase 1 (MEK1) mutant to investigate the
function of the highly conserved MEK1-ERK2 signaling module in renal epithelial cell
differentiation and proliferation. Stable expression of constitutively active MEK1 (CA-MEK1) …