[HTML][HTML] Sphingomyelinase and Ceramide Suppress Insulin-induced Tyrosine Phosphorylation of the Insulin Receptor Substrate-1 (∗)
H Kanety, R Hemi, MZ Papa, A Karasik - Journal of Biological Chemistry, 1996 - ASBMB
The sphingomyelin pathway is a newly described signal transduction pathway mediating the
action of several cytokines including tumor necrosis factor-α (TNF). TNF was recently shown
to interfere with insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1
(IRS-1). In this work we examined the possible effect of direct activation of the sphingomyelin
pathway on insulin-induced tyrosine phosphorylation of IRS-1. Incubation of the insulin-
sensitive rat hepatoma Fao cells with bacterial sphingomyelinase (SMase) that causes …
action of several cytokines including tumor necrosis factor-α (TNF). TNF was recently shown
to interfere with insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1
(IRS-1). In this work we examined the possible effect of direct activation of the sphingomyelin
pathway on insulin-induced tyrosine phosphorylation of IRS-1. Incubation of the insulin-
sensitive rat hepatoma Fao cells with bacterial sphingomyelinase (SMase) that causes …