[HTML][HTML] Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels

S Gremlich, C Bonny, G Waeber, B Thorens - Journal of Biological …, 1997 - ASBMB
IDX-1 (islet/duodenum homeobox-1) is a transcription factor expressed in the duodenum
and pancreatic beta and delta cells. It is required for embryonic development of the
pancreas and transactivates theGlut2, glucokinase, insulin, and somatostatin genes. Here
we show that exposure of isolated rat pancreatic islets to palmitic acid induced a∼ 70%
decrease in IDX-1 mRNA and protein expression as well as 40 and 65% decreases in the
binding activity of IDX-1 for its cognate cis-regulatory elements of theGlut2 and insulin …