Differential inhibition of human prostaglandin endoperoxide synthase-1 and-2 by nonsteroidal anti-inflammatory drugs

P Patrignani, MR Panara, MG Sciulli… - Journal of Physiology …, 1997 - agro.icm.edu.pl
P Patrignani, MR Panara, MG Sciulli, G Santini, G Renda, C Patrono
Journal of Physiology and Pharmacology, 1997agro.icm.edu.pl
Monocytes/macrophages release pro-inflammatory mediators in response to tissue injury or
infection. Prostaglandins (PGs) and thromboxane (TX) A, collectively termed prostanoids,
are biologically active compounds that participate in both acute and chronic inflammation.
They are formed by two successive metabolic steps: 1) arachidonic acid (AA) is released
from membranous phospholipids by phospholipase A,(PLA) which consits of two forms,
secretory (sPLA,)(1) and cytosolic (cPLA)(2); 2) free AA is converted to PGG, and then to …
Monocytes/macrophages release pro-inflammatory mediators in response to tissue injury or infection. Prostaglandins (PGs) and thromboxane (TX) A, collectively termed prostanoids, are biologically active compounds that participate in both acute and chronic inflammation. They are formed by two successive metabolic steps: 1) arachidonic acid (AA) is released from membranous phospholipids by phospholipase A,(PLA) which consits of two forms, secretory (sPLA,)(1) and cytosolic (cPLA)(2); 2) free AA is converted to PGG, and then to PGH, by the cyclooxygenase and peroxidase activities,
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