Effects of hyperglycemia on glucose transporters of the muscle: use of the renal glucose reabsorption inhibitor phlorizin to control glycemia.
D Dimitrakoudis, M Vranic, A Klip - Journal of the American …, 1992 - journals.lww.com
Individuals with non-insulin dependent or insulin-dependent diabetes mellitus present
insulin resistance in peripheral tissues. This is reflected in a subnormal whole body insulin-
dependent glucose utilization, largely dependent on skeletal muscle. Glucose transport
across the cell membrane of this tissue is rate limiting in the utilization of the hexose.
Therefore, it is possible that a defect exists in insulin-dependent glucose transport in skeletal
muscle in diabetic states. This review focuses on two questions: is there a defect at the level …
insulin resistance in peripheral tissues. This is reflected in a subnormal whole body insulin-
dependent glucose utilization, largely dependent on skeletal muscle. Glucose transport
across the cell membrane of this tissue is rate limiting in the utilization of the hexose.
Therefore, it is possible that a defect exists in insulin-dependent glucose transport in skeletal
muscle in diabetic states. This review focuses on two questions: is there a defect at the level …