[HTML][HTML] Tissue-specific Rescue Suggests That Placental Adenosine Deaminase Is Important for Fetal Development in Mice (∗)
MR Blackburn, M Wakamiya, CT Caskey… - Journal of Biological …, 1995 - ASBMB
Adenosine deaminase (ADA, EC 3.5. 4.4) is an essential enzyme of purine metabolism that
is expressed at very high levels in the murine placenta where it accounts for over 95% of the
ADA present at the fetal gestation site. We have recently shown that ADA-deficient fetuses,
which also lack ADA in their adjoining placentas, die during late fetal development in
association with profound purine metabolic disturbances and hepatocellular impairment. We
have now investigated the potential importance of placental ADA by genetically restoring the …
is expressed at very high levels in the murine placenta where it accounts for over 95% of the
ADA present at the fetal gestation site. We have recently shown that ADA-deficient fetuses,
which also lack ADA in their adjoining placentas, die during late fetal development in
association with profound purine metabolic disturbances and hepatocellular impairment. We
have now investigated the potential importance of placental ADA by genetically restoring the …