Progression to type 1 diabetes is associated with a change in the immunoglobulin isotype profile of autoantibodies to glutamic acid decarboxylase (GAD65)
JS Petersen, P Kulmala, JT Clausen, M Knip… - Clinical …, 1999 - Elsevier
To investigate whether type 1 diabetes in man is associated with a preferential Th1/Th2
response, and whether antoantibodies to one of the main autoantigens would reflect such a
response, we characterized the immunoglobulin isotype profile to the 65-kDa isoform of
glutamic acid decarboxylase (GAD65) in siblings to IDDM patients. Samples obtained from
affected subjects before and at clinical onset of IDDM, from unaffected individuals at high
risk and at low risk and from healthy controls were studied. The immunoglobulin isotype …
response, and whether antoantibodies to one of the main autoantigens would reflect such a
response, we characterized the immunoglobulin isotype profile to the 65-kDa isoform of
glutamic acid decarboxylase (GAD65) in siblings to IDDM patients. Samples obtained from
affected subjects before and at clinical onset of IDDM, from unaffected individuals at high
risk and at low risk and from healthy controls were studied. The immunoglobulin isotype …