Integrins constitute a large family of αβ heterodimeric cell surface, transmembrane proteins
that recognize a large number of extracellular ligands through a metal ion-dependent
interaction. The prescient term “integrin” reflects their role in integrating cell adhesion and
migration with the cytoskeleton (1). Their biological and medical importance is underscored
by inherited diseases causing bleeding (Glanzmann's thromasthenia) and infection
(leukocyte adhesion deficiency). Additional important roles for integrins in immune …