The role of mouse mutants in the identification of human hereditary hearing loss genes
FJ Probst, SA Camper - Hearing research, 1999 - Elsevier
The mouse is the model organism for the study of hearing loss in mammals. In recent years,
the identification of five different mutated genes in the mouse (Pax3, Mitf, Myo7a, Pou4f3,
and Myo15) has led directly to the identification of mutations in families with either
congenital sensorineural deafness or progressive sensorineural hearing loss. Each of these
cases is reviewed here. In addition to providing a powerful gateway to the identification of
human hearing loss genes, the study of mouse deafness mutants can lead to the discovery …
the identification of five different mutated genes in the mouse (Pax3, Mitf, Myo7a, Pou4f3,
and Myo15) has led directly to the identification of mutations in families with either
congenital sensorineural deafness or progressive sensorineural hearing loss. Each of these
cases is reviewed here. In addition to providing a powerful gateway to the identification of
human hearing loss genes, the study of mouse deafness mutants can lead to the discovery …