[HTML][HTML] Activation of the 92-kDa Gelatinase by Stromelysin and 4-Aminophenylmercuric Acetate: DIFFERENTIAL PROCESSING AND STABILIZATION OF THE …
SD Shapiro, CJ Fliszar, TJ Broekelmann… - Journal of Biological …, 1995 - ASBMB
The matrix metalloproteinase 92-kDa gelatinase is a major product of inflammatory cells.
Macrophages synthesize and secrete this proteinase as a proenzyme in association with
tissue inhibitor of metalloproteinases (TIMP)(92 TIMP), whereas neutrophils store and
release it from secondary granules as a TIMP-free proenzyme (92 TIMP-free).
Metalloproteinase proenzymes can be activated in vitro by a variety of agents, including
organomercurials and proteinases, resulting in loss of an 8-10-kDa NH 2-terminal domain …
Macrophages synthesize and secrete this proteinase as a proenzyme in association with
tissue inhibitor of metalloproteinases (TIMP)(92 TIMP), whereas neutrophils store and
release it from secondary granules as a TIMP-free proenzyme (92 TIMP-free).
Metalloproteinase proenzymes can be activated in vitro by a variety of agents, including
organomercurials and proteinases, resulting in loss of an 8-10-kDa NH 2-terminal domain …
