Serum Response Factor Mediates AP-1-dependent Induction of the Skeletal α-Actin Promoter in Ventricular Myocytes (∗)
P Paradis, WR MacLellan, NS Belaguli… - Journal of Biological …, 1996 - jbc.org
" Fetal" gene transcription, including activation of the skeletal α-actin (SkA) promoter, is
provoked in cardiac myocytes by mechanical stress and trophic ligands. Induction of the
promoter by transforming growth factor β or norepinephrine requires serum response factor
(SRF) and TEF-1; expression is inhibited by YY1. We and others postulated that immediate-
early transcription factors might couple trophic signals to this fetal program. However,
multiple Fos/Jun proteins exist, and the exact relationship between control by Fos/Jun …
provoked in cardiac myocytes by mechanical stress and trophic ligands. Induction of the
promoter by transforming growth factor β or norepinephrine requires serum response factor
(SRF) and TEF-1; expression is inhibited by YY1. We and others postulated that immediate-
early transcription factors might couple trophic signals to this fetal program. However,
multiple Fos/Jun proteins exist, and the exact relationship between control by Fos/Jun …
