Shear stress increases heparin-binding epidermal growth factor-like growth factor mRNA levels in human vascular endothelial cells
T Morita, M Yoshizumi, H Kurihara, K Maemura… - Biochemical and …, 1993 - Elsevier
T Morita, M Yoshizumi, H Kurihara, K Maemura, R Nagai, Y Yazaki
Biochemical and biophysical research communications, 1993•ElsevierHeparin-binding epidermal growth factor-like growth factor (HB-EGF) is a recently identified
potent vascular smooth muscle cell (SMC) mitogen. we investigated the effect of shear stress
on human HB-EGF mRNA levels in cultured human umbilical vein endothelial cells
(HUVEC). In response to shear stress (8 dyne/cm 2), HB-EGF mRNA levels in HUVEC
increased rapidly, peaked at 3 h, and returned to near base line at 7 h. The shear stress-
induced HB-EGF gene expression in HUVEC is completely blocked by 12-O-tetra …
potent vascular smooth muscle cell (SMC) mitogen. we investigated the effect of shear stress
on human HB-EGF mRNA levels in cultured human umbilical vein endothelial cells
(HUVEC). In response to shear stress (8 dyne/cm 2), HB-EGF mRNA levels in HUVEC
increased rapidly, peaked at 3 h, and returned to near base line at 7 h. The shear stress-
induced HB-EGF gene expression in HUVEC is completely blocked by 12-O-tetra …
Abstract
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a recently identified potent vascular smooth muscle cell (SMC) mitogen. we investigated the effect of shear stress on human HB-EGF mRNA levels in cultured human umbilical vein endothelial cells (HUVEC) . In response to shear stress (8 dyne/cm2), HB-EGF mRNA levels in HUVEC increased rapidly, peaked at 3 h, and returned to near base line at 7 h. The shear stress-induced HB-EGF gene expression in HUVEC is completely blocked by 12-O-tetra-decanoylphorbol-13-acetate pre-treatment, suggesting the induction of HB-EGF is mediated by protein kinase C.
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