Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues.
SD Chan, DB Karpf, ME Fowlkes, M Hooks… - Journal of Biological …, 1992 - jbc.org
The frizzled (fz) locus of Drosophila encodes a protein (Fz) with a seven-transmembrane-
domain profile characteristic of G-protein-coupled receptors. In Drosophila, genetic evidence
suggests that Fz functions to transmit and transduce polarity signals in epidermal cells
during hair and bristle development. We have isolated from a UMR 106 rat osteosarcoma
cell library a cDNA (fz-1) encoding a predicted 641-residue protein (Fz-1) with 46%
homology with Drosophila Fz. We also identified a second cDNA (fz-2) encoding a protein …
domain profile characteristic of G-protein-coupled receptors. In Drosophila, genetic evidence
suggests that Fz functions to transmit and transduce polarity signals in epidermal cells
during hair and bristle development. We have isolated from a UMR 106 rat osteosarcoma
cell library a cDNA (fz-1) encoding a predicted 641-residue protein (Fz-1) with 46%
homology with Drosophila Fz. We also identified a second cDNA (fz-2) encoding a protein …
