Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices
Y Izumi, AM Benz, CF Zorumski, JW Olney - Neuroreport, 1994 - journals.lww.com
RAT hippocampal slices were used to evaluate the effects of glucose deprivation and the
ability of lactate or pyruvate to preserve histological integrity and synaptic function. Dark cell
changes were observed during 180 min incubations in glucose-free solutions. These
changes were blocked by substituting 10 mM lactate or pyruvate for glucose during the
incubation. Excitatory postsynaptic potentials disappeared during 60 min of glucose
deprivation but were restored by subsequent introduction of glucose, lactate or pyruvate …
ability of lactate or pyruvate to preserve histological integrity and synaptic function. Dark cell
changes were observed during 180 min incubations in glucose-free solutions. These
changes were blocked by substituting 10 mM lactate or pyruvate for glucose during the
incubation. Excitatory postsynaptic potentials disappeared during 60 min of glucose
deprivation but were restored by subsequent introduction of glucose, lactate or pyruvate …
