[HTML][HTML] Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C ζ
S Pal, KP Claffey, HT Cohen… - Journal of Biological …, 1998 - ASBMB
The transcription factor Sp1 is ubiquitously expressed and plays a significant role in the
constitutive and induced expression of a variety of mammalian genes and may even
contribute to tumorigenesis. Here, we describe a novel pathway whereby Sp1 promotes the
transcription of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF), a
potent angiogenic factor, by interacting directly and specifically with protein kinase C ζ (PKC
ζ) isoform in renal cell carcinoma. PKC ζ binds and phosphorylates the zinc finger region of …
constitutive and induced expression of a variety of mammalian genes and may even
contribute to tumorigenesis. Here, we describe a novel pathway whereby Sp1 promotes the
transcription of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF), a
potent angiogenic factor, by interacting directly and specifically with protein kinase C ζ (PKC
ζ) isoform in renal cell carcinoma. PKC ζ binds and phosphorylates the zinc finger region of …
