Gatekeepers and caretakers.
KW Kinzler, B Vogelstein - Nature, 1997 - search.ebscohost.com
Nature, 1997•search.ebscohost.com
Provides background and analysis for two papers which illuminate properties of the breast-
cancer susceptibility genes BRCA1 and BRCA2. The emphasis of the important conceptual
and practical difference between gatekeeper and caretaker genes; The defining of the
biochemical and biological functions that are relevant to tumorigenesis; The paper by Milner
and others and Sharan and others in the April 24, 1997 issue ofNature.'
cancer susceptibility genes BRCA1 and BRCA2. The emphasis of the important conceptual
and practical difference between gatekeeper and caretaker genes; The defining of the
biochemical and biological functions that are relevant to tumorigenesis; The paper by Milner
and others and Sharan and others in the April 24, 1997 issue ofNature.'
Abstract
Provides background and analysis for two papers which illuminate properties of the breast-cancer susceptibility genes BRCA1 and BRCA2. The emphasis of the important conceptual and practical difference between gatekeeper and caretaker genes; The defining of the biochemical and biological functions that are relevant to tumorigenesis; The paper by Milner and others and Sharan and others in the April 24, 1997 issue ofNature.'
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