DNA tumor virus transforming proteins and the cell cycle
E Moran - Current opinion in genetics & development, 1993 - Elsevier
E Moran
Current opinion in genetics & development, 1993•ElsevierStudies using the transforming proteins of the small DNA tumor viruses point to the role of
the E2F cellular transcription factor in regulating cell cycle specific gene expression. The
evidence derived suggests that E2F is controlled by the retinoblastoma gene product and
related proteins, including their associated cyclins. Studies using DNA tumor virus products
further suggest the existence of additional pathways of cell-cycle activation.
the E2F cellular transcription factor in regulating cell cycle specific gene expression. The
evidence derived suggests that E2F is controlled by the retinoblastoma gene product and
related proteins, including their associated cyclins. Studies using DNA tumor virus products
further suggest the existence of additional pathways of cell-cycle activation.
Studies using the transforming proteins of the small DNA tumor viruses point to the role of the E2F cellular transcription factor in regulating cell cycle specific gene expression. The evidence derived suggests that E2F is controlled by the retinoblastoma gene product and related proteins, including their associated cyclins. Studies using DNA tumor virus products further suggest the existence of additional pathways of cell-cycle activation.
Elsevier
