Chylomicron/chylomicron remnant turnover in humans: evidence for margination of chylomicrons and poor conversion of larger to smaller chylomicron remnants
The size of cholesterol-rich lipoprotein particles is a strong determinant of whether they may
be deposited in the arterial wall and by this become potentially atherogenic. This study deals
with the in vivo transformation of larger-sized chylomicrons and chylomicron remnants to
smaller-sized remnants. Twelve healthy men aged 22 to 45 years were given a fatty meal to
which retinyl palmitate (RP) had been added. Plasmapheresis was performed 4 1/2 h after
meal intake to isolate approximately 400 ml plasma. The RP-rich plasma was re-injected to …
be deposited in the arterial wall and by this become potentially atherogenic. This study deals
with the in vivo transformation of larger-sized chylomicrons and chylomicron remnants to
smaller-sized remnants. Twelve healthy men aged 22 to 45 years were given a fatty meal to
which retinyl palmitate (RP) had been added. Plasmapheresis was performed 4 1/2 h after
meal intake to isolate approximately 400 ml plasma. The RP-rich plasma was re-injected to …
