The goal of this investigation was to determine whether participation in an atherosclerosis
treatment program would reduce the oxidative susceptibility of LDL from patients with
coronary artery disease. The treatment program included intensive exercise therapy, stress
management, and consumption of a diet containing 10% fat. The size and antioxidant and
lipid contents of LDL particles from 25 patients were analyzed at baseline and after 3 mo of
therapy. The susceptibility of LDL to copper-mediated oxidation was measured by a …