[HTML][HTML] Biologically active oxidized phospholipids

TM McIntyre, GA Zimmerman, SM Prescott - Journal of Biological Chemistry, 1999 - ASBMB
Oxidants and free radicals are deleterious in many ways, and organisms employ numerous
approaches to block their production or limit their damage. Hydrogen atoms adjacent to
olefinic bonds are susceptible to oxidative attack and those between unconjugated olefinic
bonds especially so. Lipids are a rich source of these bonds and so are a primary target for
oxidative reactions. Lipid oxidation is problematic as the many oxidative chemical reactions
are not controlled and constrained by enzymes and may show exponential reaction rates …