[HTML][HTML] Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis
M Horiuchi, W Hayashida, T Kambe, T Yamada… - Journal of Biological …, 1997 - ASBMB
We examined the cellular and signaling mechanism of angiotensin II (Ang II) type 2 (AT2)
receptor-induced apoptosis in PC12W (rat pheochromocytoma cell line) cells that express
abundant AT2 receptor but not Ang II type 1 receptor. In these cells, nerve growth factor
(NGF) inhibited the internucleosomal DNA fragmentation induced by serum depletion,
whereas Ang II antagonized this NGF cell survival action and induced apoptosis. We studied
the mechanism of NGF and AT2 receptor interaction on apoptosis by examining their effects …
receptor-induced apoptosis in PC12W (rat pheochromocytoma cell line) cells that express
abundant AT2 receptor but not Ang II type 1 receptor. In these cells, nerve growth factor
(NGF) inhibited the internucleosomal DNA fragmentation induced by serum depletion,
whereas Ang II antagonized this NGF cell survival action and induced apoptosis. We studied
the mechanism of NGF and AT2 receptor interaction on apoptosis by examining their effects …