Elevated in vivo expression of the costimulatory molecule B7-BB1 (CD80) on antigen presenting cells from a patient with SLE.
B Kovacs, DE Thomas, GC Tsokos - Clinical and experimental …, 1996 - europepmc.org
B Kovacs, DE Thomas, GC Tsokos
Clinical and experimental rheumatology, 1996•europepmc.orgThe CD28/CTLA4-B7-family plays an important role in T-cell costimulation and is crucial for
IL-2 production and tolerance induction. The costimulatory molecule B7-BB1 (CD80) is
expressed on activated antigen presenting cells, but its expression on peripheral blood
mononuclear cells is very low. Here we report a patient with untreated SLE whose
peripheral blood antigen presenting cells expressed increased amounts of B7-BB1.
IL-2 production and tolerance induction. The costimulatory molecule B7-BB1 (CD80) is
expressed on activated antigen presenting cells, but its expression on peripheral blood
mononuclear cells is very low. Here we report a patient with untreated SLE whose
peripheral blood antigen presenting cells expressed increased amounts of B7-BB1.
The CD28/CTLA4-B7-family plays an important role in T-cell costimulation and is crucial for IL-2 production and tolerance induction. The costimulatory molecule B7-BB1 (CD80) is expressed on activated antigen presenting cells, but its expression on peripheral blood mononuclear cells is very low. Here we report a patient with untreated SLE whose peripheral blood antigen presenting cells expressed increased amounts of B7-BB1.
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