Tumor necrosis factor-α facilitates induction of CD80 (B7-1) and CD54 on human B cells by activated T cells: complex regulation by IL-4, IL-10, and CD40L
EA Ranheim, TJ Kipps - Cellular immunology, 1995 - Elsevier
Expression of immune accessory molecules, such as CD80 (B7-1), on antigen-presenting
cells governs whether such cells can activate antigen-specific T cells. As such, the factors
that regulate the expression of these accessory molecules may determine whether
presentation of antigen leads to immune activation or anergy. We previously reported that
anti-CD3-activated T cells (Ta) can induce expression of CD80 and CD54 (ICAM-1) on
human B cells through a contact-dependent signal delivered to the CD40 molecule via the …
cells governs whether such cells can activate antigen-specific T cells. As such, the factors
that regulate the expression of these accessory molecules may determine whether
presentation of antigen leads to immune activation or anergy. We previously reported that
anti-CD3-activated T cells (Ta) can induce expression of CD80 and CD54 (ICAM-1) on
human B cells through a contact-dependent signal delivered to the CD40 molecule via the …