Anti‐dsDNA and complement profiles as prognostic guides in systemic lupus erythematosus
AJG Swaak, LA Aarden… - … : Official Journal of …, 1979 - Wiley Online Library
AJG Swaak, LA Aarden, LWV Statius Eps, TEW Feltkamp
Arthritis & Rheumatism: Official Journal of the American College …, 1979•Wiley Online LibraryAntibodies to dsDNA, tested with circular DNA in the Farr assay, are specific for systemic
lupus erythematosus. A longitudinal study showed a clear relation between the clinical state,
the anti‐dsDNA titer (expressed in units), and the C1q and C3 levels: when anti‐dsDNA
levels remained high, no exacerbations were observed. A sharp drop in anti‐dsDNA, usually
preceded by a rise, was related to a serious exacerbation. Only during the exacerbation
when both C1q and C3 were very low was renal involvement seen.
lupus erythematosus. A longitudinal study showed a clear relation between the clinical state,
the anti‐dsDNA titer (expressed in units), and the C1q and C3 levels: when anti‐dsDNA
levels remained high, no exacerbations were observed. A sharp drop in anti‐dsDNA, usually
preceded by a rise, was related to a serious exacerbation. Only during the exacerbation
when both C1q and C3 were very low was renal involvement seen.
Abstract
Antibodies to dsDNA, tested with circular DNA in the Farr assay, are specific for systemic lupus erythematosus. A longitudinal study showed a clear relation between the clinical state, the anti‐dsDNA titer (expressed in units), and the C1q and C3 levels: when anti‐dsDNA levels remained high, no exacerbations were observed. A sharp drop in anti‐dsDNA, usually preceded by a rise, was related to a serious exacerbation. Only during the exacerbation when both C1q and C3 were very low was renal involvement seen.
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