[HTML][HTML] Electron paramagnetic resonance and oxygen binding studies of α-nitrosyl hemoglobin: a novel oxygen carrier having NO-assisted allosteric functions
T Yonetani, A Tsuneshige, Y Zhou, X Chen - Journal of Biological …, 1998 - ASBMB
α-Nitrosyl hemoglobin, α (Fe-NO) 2 β (Fe) 2, which is frequently observed upon reaction of
deoxy hemoglobin with limited quantities of NO in vitro as well as in vivo, has been
synthetically prepared, and its reaction with O 2 has been investigation by EPR and
thermodynamic equilibrium measurements. α-Nitrosyl hemoglobin is relatively stable under
aerobic conditions and undergoes reversible O 2 binding at the heme sites of its β-subunits.
Its O 2 binding is coupled to the structural/functional transition between T-(low affinity …
deoxy hemoglobin with limited quantities of NO in vitro as well as in vivo, has been
synthetically prepared, and its reaction with O 2 has been investigation by EPR and
thermodynamic equilibrium measurements. α-Nitrosyl hemoglobin is relatively stable under
aerobic conditions and undergoes reversible O 2 binding at the heme sites of its β-subunits.
Its O 2 binding is coupled to the structural/functional transition between T-(low affinity …