A dramatic increase in liner growth velocity, often referred to as the pubertal growth spurt, is
a central feature of pubertal development. Despite the existence of numerous investigative
attempts, a precise understanding of the hormonal events subserving this process has
proved elusive. Nevertheless, evidence has gradually accumulated that indicates that sex
steroid-induced modulation of growth hormone secretion is a central and critical feature of
the pubertal growth spurt. As a result, disorders of either growth hormone or sex steroid …