Chronic neurologic disease in Theiler's virus infection of SJL/J mice
HL Lipton, MC Dal Canto - Journal of the neurological sciences, 1976 - Elsevier
This study demonstrates that most SJL/J mice inoculated intracerebrally (IC) with 1000
suckling mouse 50% mean lethal doses of Theiler's encephalomyelitis virus (TMEV) develop
flaccid paralysis 10–21 days after infection when there is acute spinal cord gray matter
involvement (early disease). Surviving mice later develop a distinctive chronic neurologic
disorder which is associated with marked mononuclear cell infiltrates and active
demyelination in spinal cord white matter (late disease). Moreover, about one-fourth of …
suckling mouse 50% mean lethal doses of Theiler's encephalomyelitis virus (TMEV) develop
flaccid paralysis 10–21 days after infection when there is acute spinal cord gray matter
involvement (early disease). Surviving mice later develop a distinctive chronic neurologic
disorder which is associated with marked mononuclear cell infiltrates and active
demyelination in spinal cord white matter (late disease). Moreover, about one-fourth of …