Effect of recombinant human insulin-like growth factor-1 on the inflammatory response to acute renal injury.
N Goes, J Urmson, D Vincent, V Ramassar… - Journal of the …, 1996 - journals.lww.com
Renal ischemic injury evokes an inflammatory response with increased cytokine and major
histocompatibility complex (MHC) expression and a mild interstitial infiltrate. This" injury
response" could contribute to the tendency of ischemically injured renal transplants to reject.
The studies presented here evaluated the ability of recombinant human insulin-like growth
factor-1 (rhlGF-1) given after renal injury to prevent renal inflammation. The left renal pedicle
of CBA and BALB/c mice was clamped for 60 min, and rhlGF-1 (25, 50, 100 micrograms) …
histocompatibility complex (MHC) expression and a mild interstitial infiltrate. This" injury
response" could contribute to the tendency of ischemically injured renal transplants to reject.
The studies presented here evaluated the ability of recombinant human insulin-like growth
factor-1 (rhlGF-1) given after renal injury to prevent renal inflammation. The left renal pedicle
of CBA and BALB/c mice was clamped for 60 min, and rhlGF-1 (25, 50, 100 micrograms) …