Increased frequency of homozygosity of abnormal mannan-binding-protein alleles in patients with suspected immunodeficiency.
P Garred, HO Madsen, B Hofmann… - Lancet (London …, 1995 - europepmc.org
P Garred, HO Madsen, B Hofmann, A Svejgaard
Lancet (London, England), 1995•europepmc.orgA low plasma concentration of mannan-binding protein (MBP) impairs opsonisation and
phagocytosis. Three different mutations in the MBP gene have a dominant effect on MBP
concentration. We investigated the frequency of the abnormal MBP alleles in 228 unrelated
patients suspected of various non-HIV-related immunodeficiencies. The frequency of
heterozygotes for the abnormal alleles was not different from that in the background
population (36.0% and 37.4%, respectively). By contrast, the frequency of homozygotes for …
phagocytosis. Three different mutations in the MBP gene have a dominant effect on MBP
concentration. We investigated the frequency of the abnormal MBP alleles in 228 unrelated
patients suspected of various non-HIV-related immunodeficiencies. The frequency of
heterozygotes for the abnormal alleles was not different from that in the background
population (36.0% and 37.4%, respectively). By contrast, the frequency of homozygotes for …
A low plasma concentration of mannan-binding protein (MBP) impairs opsonisation and phagocytosis. Three different mutations in the MBP gene have a dominant effect on MBP concentration. We investigated the frequency of the abnormal MBP alleles in 228 unrelated patients suspected of various non-HIV-related immunodeficiencies. The frequency of heterozygotes for the abnormal alleles was not different from that in the background population (36.0% and 37.4%, respectively). By contrast, the frequency of homozygotes for the abnormal alleles was significantly increased (8.3% and 0.8%, respectively; p= 0.0017). This finding implies that homozygotes for abnormal MBP alleles are predisposed to recurrent infections.
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